Expert Answer :Seminar report


Solved by verified expert:Seminar Report Dr. Carmen DessauerAKAPs and Adenylyl Cyclase: the Next Dimension in cAMP Signaling Univ. of TexasSeminar format and voice record are attached (1 page)


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A. Reports (50 points). You will submit your report (~1/2 to 1 page,
single spaced) by uploading it into the Turnitin folder in the course
Blackboard site on any five of the seminars. In the report, you will include
the six items noted below. The report format and rubric are located at
the end of this syllabus.
● Your name
● Presentation date, speaker name, presentation title and academic affiliation
● State the main hypothesis or question (Hypothesis)
● Describe the main method or approach (Approach)
● Describe at least two main findings (Results)
● Discuss whether the results supported of not the original hypothesis
Hypothesis. The main hypothesis of this seminar is….
Approach. The approaches used for this talk are novel. First, they used …
Result. Main results of this presentation are …
Discussion. The original hypothesis of
were mostly addressed by
results, but I don’t think it was
completely proved because…
California State University, Fresno
Presented by the Bridges to Doctorate Program with UC Merced
AKAPs and Adenylyl Cyclase: the Next Dimension
in cAMP Signaling
Carmen Dessauer, Ph. D.
Professor and Vice-Chair
Dept. of Integrative Biology and Pharmacology
McGovern Medical School
University of Texas Health Science Center, Houston, TX
Friday, February 23, 3:00 PM
Science 2, room 109
The overall goal of my laboratory is to understand the regulation of adenylyl cyclase/cyclic AMP
signaling in physiological and pathophysiological states. Over the years, we have elucidated
mechanisms of adenylyl cyclase regulation by RGS proteins, heterotrimeric G protein alpha and betagamma subunits, and protein kinases. More recently we have explored the spatial and temporal
regulation of cAMP signaling and identified scaffolding proteins, known as A Kinase Anchoring
Proteins (AKAPs) that can bind to specific isoforms of adenylyl cyclase to temporally and spatially
regulate cyclic AMP. These complexes clearly shape the dynamics of cyclic AMP production in terms
of the magnitude of the signal, the temporal nature of PKA activation, and regulation of specific
downstream targets, including TrpV1 and IKs (KCNQ1) channels. Projects in the lab include 1) kinetic
and mechanistic studies of enzyme regulation, 2) roles for AKAPs and other scaffolding proteins in
the spatial kinetics of adenylyl cyclase and cAMP signaling, 3) physiological roles for type 9 adenylyl
cyclase in heart, and 4) pathophysiological roles for cAMP signaling in chronic pain after spinal cord
If you need a disability-related accommodation or wheelchair access, please contact Lindasue Garner at the Department of Biology at
278-2001 or e-mail (at least one week prior to event).

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