Solved by verified expert:Read the attached article. Note the changes in death rates and how they
seem to be associated with education, and poisonings, suicide, and liver
disease contributing to much of the increase, especially in those with a
lower level of education. How would level of education be somewhat
protective against death in midlife? Discuss in 750 words.
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Rising morbidity and mortality in midlife among white
non-Hispanic Americans in the 21st century
Anne Case1 and Angus Deaton1
Woodrow Wilson School of Public and International Affairs and Department of Economics, Princeton University, Princeton, NJ 08544
Contributed by Angus Deaton, September 17, 2015 (sent for review August 22, 2015; reviewed by David Cutler, Jon Skinner, and David Weir)
This paper documents a marked increase in the all-cause mortality of
middle-aged white non-Hispanic men and women in the United States
between 1999 and 2013. This change reversed decades of progress in
mortality and was unique to the United States; no other rich country
saw a similar turnaround. The midlife mortality reversal was confined
to white non-Hispanics; black non-Hispanics and Hispanics at midlife,
and those aged 65 and above in every racial and ethnic group, continued to see mortality rates fall. This increase for whites was largely
accounted for by increasing death rates from drug and alcohol poisonings, suicide, and chronic liver diseases and cirrhosis. Although all
education groups saw increases in mortality from suicide and poisonings, and an overall increase in external cause mortality, those with less
education saw the most marked increases. Rising midlife mortality
rates of white non-Hispanics were paralleled by increases in midlife
morbidity. Self-reported declines in health, mental health, and ability
to conduct activities of daily living, and increases in chronic pain and
inability to work, as well as clinically measured deteriorations in liver
function, all point to growing distress in this population. We comment
on potential economic causes and consequences of this deterioration.
| morbidity | US white non-Hispanics
here has been a remarkable long-term decline in mortality rates
in the United States, a decline in which middle-aged and older
adults have fully participated (1‒3). Between 1970 and 2013, a
combination of behavioral change, prevention, and treatment (4, 5)
brought down mortality rates for those aged 45–54 by 44%. Parallel
improvements were seen in other rich countries (2). Improvements
in health also brought declines in morbidity, even among the increasingly long-lived elderly (6‒9).
These reductions in mortality and morbidity have made lives
longer and better, and there is a general and well-based presumption
that these improvements will continue. This paper raises questions
about that presumption for white Americans in midlife, even as
mortality and morbidity continue to fall among the elderly.
This paper documents a marked deterioration in the morbidity
and mortality of middle-aged white non-Hispanics in the United
States after 1998. General deterioration in midlife morbidity among
whites has received limited comment (10, 11), but the increase in allcause midlife mortality that we describe has not been previously
highlighted. For example, it does not appear in the regular mortality
and health reports issued by the CDC (12), perhaps because its
documentation requires disaggregation by age and race. Beyond that,
the extent to which the episode is unusual requires historical context,
as well as comparison with other rich countries over the same period.
Increasing mortality in middle-aged whites was matched by increasing morbidity. When seen side by side with the mortality
increase, declines in self-reported health and mental health, increased reports of pain, and greater difficulties with daily living
show increasing distress among whites in midlife after the late
1990s. We comment on potential economic causes and consequences of this deterioration.
Fig. 1 shows age 45–54 mortality rates for US white non-Hispanics
(USW, in red), US Hispanics (USH, in blue), and six rich industrialized comparison countries: France (FRA), Germany (GER),
15078–15083 | PNAS | December 8, 2015 | vol. 112 | no. 49
the United Kingdom (UK), Canada (CAN), Australia (AUS), and
Sweden (SWE). The comparison is similar for other Organisation
for Economic Co-operation and Development countries.
Fig. 1 shows a cessation and reversal of the decline in midlife
mortality for US white non-Hispanics after 1998. From 1978 to 1998,
the mortality rate for US whites aged 45–54 fell by 2% per year on
average, which matched the average rate of decline in the six countries shown, and the average over all other industrialized countries.
After 1998, other rich countries’ mortality rates continued to decline
by 2% a year. In contrast, US white non-Hispanic mortality rose by
half a percent a year. No other rich country saw a similar turnaround.
The mortality reversal was confined to white non-Hispanics; Hispanic
Americans had mortality declines indistinguishable from the British
(1.8% per year), and black non-Hispanic mortality for ages 45–54
declined by 2.6% per year over the period.
For deaths before 1989, information on Hispanic origin is not
available, but we can calculate lives lost among all whites. For those
aged 45–54, if the white mortality rate had held at its 1998 value,
96,000 deaths would have been avoided from 1999 to 2013, 7,000
in 2013 alone. If it had continued to fall at its previous (1979‒1998)
rate of decline of 1.8% per year, 488,500 deaths would have been
avoided in the period 1999‒2013, 54,000 in 2013. (Supporting Information provides details on calculations.)
This turnaround, as of 2014, is specific to midlife. All-cause
mortality rates for white non-Hispanics aged 65–74 continued to
fall at 2% per year from 1999 to 2013; there were similar declines
in all other racial and ethnic groups aged 65–74. However, the
mortality decline for white non-Hispanics aged 55–59 also slowed,
declining only 0.5% per year over this period.
Midlife increases in suicides and drug poisonings have been previously noted. However, that these upward trends were persistent and large enough to drive up all-cause midlife mortality has,
to our knowledge, been overlooked. If the white mortality rate
for ages 45−54 had held at their 1998 value, 96,000 deaths would
have been avoided from 1999–2013, 7,000 in 2013 alone. If it had
continued to decline at its previous (1979‒1998) rate, half a million
deaths would have been avoided in the period 1999‒2013, comparable to lives lost in the US AIDS epidemic through mid-2015.
Concurrent declines in self-reported health, mental health, and
ability to work, increased reports of pain, and deteriorating measures of liver function all point to increasing midlife distress.
Author contributions: A.C. and A.D. designed research, performed research, analyzed
data, and wrote the paper.
Reviewers: D.C., Harvard University; J.S., Dartmouth College; and D.W., Institute for
The authors declare no conflict of interest.
Freely available online through the PNAS open access option.
See Commentary on page 15006.
To whom correspondence may be addressed. Email: firstname.lastname@example.org or Deaton@
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.
Fig. 1. All-cause mortality, ages 45–54 for US White non-Hispanics (USW),
US Hispanics (USH), and six comparison countries: France (FRA), Germany
(GER), the United Kingdom (UK), Canada (CAN), Australia (AUS), and Sweden (SWE).
There was a pause in midlife mortality decline in the 1960s,
largely explicable by historical patterns of smoking (13). Otherwise,
the post-1999 episode in midlife mortality in the United States is both
historically and geographically unique, at least since 1950. The turnaround is not a simple cohort effect; Americans born between 1945
and 1965 did not have particularly high mortality rates before midlife.
Fig. 2 presents the three causes of death that account for the
mortality reversal among white non-Hispanics, namely suicide, drug
and alcohol poisoning (accidental and intent undetermined), and
chronic liver diseases and cirrhosis. All three increased year-on-year
after 1998. Midlife increases in suicides and drug poisonings have
been previously noted (14–16). However, that these upward trends
were persistent and large enough to drive up all-cause midlife mortality has, to our knowledge, been overlooked. For context, Fig. 2 also
presents mortality from lung cancer and diabetes. The obesity epidemic has (rightly) made diabetes a major concern for midlife
Americans; yet, in recent history, death from diabetes has not been
an increasing threat. Poisonings overtook lung cancer as a cause of
death in 2011 in this age group; suicide appears poised to do so.
Table 1 shows changes in mortality rates from 1999 to 2013 for
white non-Hispanic men and women ages 45–54 and, for comparison, changes for black non-Hispanics and for Hispanics. The
table also presents changes in mortality rates for white non-Hispanics by three broad education groups: those with a high school
degree or less (37% of this subpopulation over this period), those
with some college, but no bachelor’s (BA) degree (31%), and those
with a BA or more (32%). The fraction of 45- to 54-y-olds in the
three education groups was stable over this period. Each cell shows
the change in the mortality rate from 1999 to 2013, as well as its
level (deaths per 100,000) in 2013.
Over the 15-y period, midlife all-cause mortality fell by more
than 200 per 100,000 for black non-Hispanics, and by more than
60 per 100,000 for Hispanics. By contrast, white non-Hispanic
mortality rose by 34 per 100,000. The ratio of black non-Hispanic
to white non-Hispanic mortality rates for ages 45–54 fell from
Case and Deaton
chronic liver diseases
Mortality by cause, white non-Hispanics ages 45–54.
PNAS | December 8, 2015 | vol. 112 | no. 49 | 15079
deaths per 100,000
deaths per 100,000
2.09 in 1999 to 1.40 in 2013. CDC reports have highlighted the
narrowing of the black−white gap in life expectancy (12). However, for ages 45–54, the narrowing of the mortality rate ratio in
this period was largely driven by increased white mortality; if
white non-Hispanic mortality had continued to decline at 1.8%
per year, the ratio in 2013 would have been 1.97. The role played
by changing white mortality rates in the narrowing of the black
−white life expectancy gap (2003−2008) has been previously
noted (17). It is far from clear that progress in black longevity
should be benchmarked against US whites.
The change in all-cause mortality for white non-Hispanics 45–54 is
largely accounted for by an increasing death rate from external
causes, mostly increases in drug and alcohol poisonings and in suicide. (Patterns are similar for men and women when analyzed separately.) In contrast to earlier years, drug overdoses were not
concentrated among minorities. In 1999, poisoning mortality for ages
45–54 was 10.2 per 100,000 higher for black non-Hispanics than
white non-Hispanics; by 2013, poisoning mortality was 8.4 per
100,000 higher for whites. Death from cirrhosis and chronic liver
diseases fell for blacks and rose for whites. After 2006, death rates
from alcohol- and drug-induced causes for white non-Hispanics
exceeded those for black non-Hispanics; in 2013, rates for white nonHispanic exceeded those for black non-Hispanics by 19 per 100,000.
The three numbered rows of Table 1 show that the turnaround
in mortality for white non-Hispanics was driven primarily by increasing death rates for those with a high school degree or less.
All-cause mortality for this group increased by 134 per 100,000
between 1999 and 2013. Those with college education less than a
BA saw little change in all-cause mortality over this period; those
with a BA or more education saw death rates fall by 57 per
100,000. Although all three educational groups saw increases in
mortality from suicide and poisonings, and an overall increase in
external cause mortality, increases were largest for those with the
least education. The mortality rate from poisonings rose more
than fourfold for this group, from 13.7 to 58.0, and mortality from
chronic liver diseases and cirrhosis rose by 50%. The final two
rows of the table show increasing educational gradients from 1999
Table 1. Changes in mortality rates 2013–1999, ages 45–54 (2013 mortality rates)
15080 | www.pnas.org/cgi/doi/10.1073/pnas.1518393112
Increases in midlife mortality are paralleled by increases in selfreported midlife morbidity. Table 2 presents measures of selfassessed health status, pain, psychological distress, difficulties
with activities of daily living (ADLs), and alcohol use. Each row
presents the average fraction of white non-Hispanics ages 45–54
who reported a given health condition in surveys over 2011–2013,
followed by the change in the fraction reporting that condition
between survey years 1997−1999 and 2011−2013, together with the
95% confidence interval (CI) on the size of that change.
The first two rows of Table 2 present the fraction of respondents who reported excellent or very good health and fair or poor
health. There was a large and statistically significant decline in the
fraction reporting excellent or very good health (6.7%), and a
corresponding increase in the fraction reporting fair or poor health
(4.3%). This deterioration in self-assessed health is observed in each
US state analyzed separately (results omitted for reasons of space).
On average, respondents in the later period reported an additional
full day in the past 30 when physical health was “not good.”
The increase in reports of poor health among those in midlife was
matched by increased reports of pain. Rows 4–7 of Table 2 present
the fraction reporting neck pain, facial pain, chronic joint pain, and
sciatica. One in three white non-Hispanics aged 45–54 reported
chronic joint pain in the 2011–2013 period; one in five reported neck
pain; and one in seven reported sciatica. Reports of all four types of
pain increased significantly between 1997−1999 and 2011−2013: An
additional 2.6% of respondents reported sciatica or chronic joint
pain, an additional 2.3% reported neck pain, and an additional 1.3%
reported facial pain.
The fraction of respondents in serious psychological distress
also increased significantly. Results from the Kessler six (K6)
questionnaire show that the fraction of people who were
scored in the range of serious mental illness rose from 3.9% to
4.8% over this period. Compared with 1997–99, respondents in
2011–2013 reported an additional day in the past month when
their mental health was not good.
Table 2 also reports the fraction of people who respond that they
have more than “a little difficulty” with ADLs. Over this period,
there was significant midlife deterioration, on the order of 2–3
percentage points, in walking a quarter mile, climbing 10 steps,
standing or sitting for 2 h, shopping, and socializing with friends.
The fraction of respondents reporting difficulty in socializing, a risk
factor for suicide (18, 19), increased by 2.4 percentage points.
and 2013; the ratio of midlife all-cause mortality of the lowest to
the highest educational group rose from 2.6 in 1999 to 4.1 in 2013.
Fig. 3 shows the temporal and spatial joint evolution of suicide
and poisoning mortality for white non-Hispanics aged 45–54, for
every-other year from 1999 to 2013, for each of the four census
regions of the United States. Death rates from these causes increased in parallel in all four regions between 1999 and 2013.
Suicide rates were higher in the South (marked in black) and the
West (green) than in the Midwest (red) or Northeast (blue) at
the beginning of this period, but in each region, an increase in
suicide mortality of 1 per 100,000 was matched by a 2 per 100,000
increase in poisoning mortality.
The focus of this paper is on changes in mortality and morbidity
for those aged 45–54. However, as Fig. 4 makes clear, all 5-y age
groups between 30–34 and 60–64 have witnessed marked and
similar increases in mortality from the sum of drug and alcohol
poisoning, suicide, and chronic liver disease and cirrhosis over the
period 1999–2013; the midlife group is different only in that the
sum of these deaths is large enough that the common growth rate
changes the direction of all-cause mortality.
WNH by education class
1. Less than high school
or HS degree only
2. Some college, no BA
3. BA degree or more
Ratios of rates groups 1–3
Fig. 3. Census region-level suicide and poisoning mortality rates 1999–2013.
Census regions are Northeast (blue), Midwest (red), South (black), and West
Case and Deaton
poisoning, suicide, and liver mortality
Fig. 4. Mortality by poisoning, suicide, chronic liver disease, and cirrhosis,
white non-Hispanics by 5-y age group.
Respondents reporting that their activities are limited by physical
or mental health increased by 3.2 percentage points. The fraction
reporting being unable to work doubled for white non-Hispanics
aged 45–54 in this 15-y period.
Increasing obesity played only a part in this deterioration of
midlife self-assessed health, mental health, reported pain, and difficulties with ADLs. Respondents with body mass indices above 30
reported greater morbidity along all of these dimensions. However,
deterioration in midlife morbidity occurred for both obese and
nonobese respondents, and increased prevalence of obesity accounts for only a small fraction of the overall deterioration.
Risk for heavy drinking—more than one (two) drinks daily for
women (men)—also increased significantly. Blood tests show
increases in the fraction of participants with elevated levels of
aspartate aminotransferase (AST) and alanine aminotransferase
(ALT) enzymes, indicators for potential inflammation of, or damage to, the liver. Nonalcoholic fatty liver disease can also elevate
AST and ALT enzymes; for this reason, we show the fractions with
elevated enzymes among all respondents, and separately for nonobese respondents (those with body mass index < 30). As was true in comparisons of mortality rate changes, where midlife groups fared worse than the elderly, most of these morbidity indicators either held constant or improved among older populations over this period. With the exception of neck pain and facial pain, and enzyme test results (for which census region markers are not available), the temporal evolution of each morbidity marker presented in Table 2 is significantly associated with the temporal evolution of suicide and poisonings within census region. (Supporting Information provides details.) Discussion The increase in midlife morbidity and mortality among US white non-H ... Purchase answer to see full attachment
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